Pharmacological activity anticancer activity in ayurveda, various plants are used as a potential source of anticancer and antitumor properties. Page 1 queen of herbs tulsi ocimum sanctum removes impurities from water and plays disinfectant role babita labh kayastha 1 1. Different parts of plant ocimum sanctum possess anticancer, antifertility, antidiabetic, antifungal, hepatoprotective, cardioprotective and analgesic properties. Potentiating effect of betacaryophyllene on anticancer activity of alphahumulene, isocaryophyllene and paclitaxel. Ocimum sanctum or holy basil is an ancient herb popular for its curative properties to treat number of health disorders. These observations clearly indicate ocimum sanctum extracts possess anticancer activity.
Labiateae or lamiaceae comprises 30 species which are found in tropical and subtropical regions. Therapeutic activities of ocimum tenuiflorum accounted in. Review article pharmacological activities of ocimum. Anxiety and depression are the major psychological disorder found in people all over the globe. Experimental studies identify it to be a highly promising immunomodulator, cytoprotective and anticancer agent. In vitro antioxidant and antineoplastic activities of. Ocimum sanctum is an aromatic plant in the family lamiaceae which is native to the indian subcontinent. Whole plant extracts ethanol extracted were prepared, coded as plant extract numbers 117, and tested for their potential as anticancer agents. Administration of aqueous and ethanolic extracts of ocimum sanctum to mice bearing sarcoma180 solid tumors mediated a significant reduction in tumor volume and an increase in lifespan.
P sims college of pharmacy, mangaldas nagar, guntur, a. An overview article pdf available july 20 with 5,622 reads. Ocimum tenuiflorum ocimum sanctum belongs to the family of lamiaceae and is commonly known as thulasitulsi in india. Different parts of the plant to be effectively in a number of diseases 16. Antioxidant potential of the os extract was evaluated in vitro by dpph 1, 1diphenyl2picrylhydrazyl and no nitric oxide scavenging assay and reducing power assay method. Os extract showed prominent scavenging activity in all the methods with.
Anticancer property of ocimum sanctum the experimental studies carried out on biological models using os extract on fibrosarcoma cells in culture have demonstrated that ocimum sanctum exhibits anticancer activity. Screening of siddha medicinal plants for anti cancer. A plant from genus ocimum among the plants known for medicinal value, the plants of genus ocimum belonging to family labiatae are very important for their therapeutic potentials. The plant increased the physical endurance and prevented stressinduced ulcers. Circineol, gallic acid, vitamin a, vitamin c, phosphrous and iron. Keywords ocimum sanctum, expectorant, stimulant, anthelmentic. Ocimum sanctum is an annual herb belonging to the mint family with 150 varieties worldwide. In the steps, the four dried fractions were extracted and used for biogenic synthesis of gold nanoparticles. Pdf in vitro and in vivo methods for anticancer activity.
Evaluation of cardioprotective activity of ginkgo biloba. Evaluating medicinal plants for anticancer activity. Studies of antimicrobial properties of different leaf. Therapeutic potential and phytopharmacology of tulsi. Ocimum sanctum is held sacred by hindus and is used as medicinal plants in day to day practice in indian homes for various ailments. Pdf study of invitro antioxidant and antibacterial. Qu has been conjugated with nigs for enhanced anticancer effect on human breast cancer mcf7 cells. A potential source of anticancer agent and its role in restoration of maspin via snail and hdacs in breast cancer thesis submitted to.
The medicinal value of this herb is recognised by ayurveda. The genus ocimum has a number of species that are used to treat different types of disorders and diseases from ancient times. Diversified potentials of ocimum sanctum linn tulsi. Evaluation of some chemical composition, minerals fatty acid profiles, antioxidant and antimicrobial activities of tulsi ocimum sanctum from india. The results of antioxidant activity of tulsi leaves extract showed that tulsi leaves has good free radical scavenging ability and ic50 value was found to be 54. The phytochemical study of the nonpolar dichloromethane 100% and polar methanol. P, india abstract ocimum sanctum is an annual herb belonging to the mint family with 150 varieties worldwide. Formulation, evaluation and antibacterial efficiency of. Ocimum sanctum linn is preeminent, and scientific research is now confirming its beneficial effects. Tulsi named as queen of herbs of india and one of the holiest and. Introduction tulsi is an important symbol of the hindu religious.
In vitro tests on oral pathogenic bacteria shows that ocimum sanctum l extract in the form of toothpastes, mouthwash, and gels have antibacterial activity against streptococcus mutans and. Tulsi in hindi is an important medicinal plant, traditionally used in india. Therapeutic potential of ocimum sanctum in prevention and. Treatment with an ethanolic extract of ocimum sanctum induced cytotoxicity at 50 gml and above.
Ayurvedic system of medicine of ocimum sanctum for various aliment and has been show to significant antistress property. Synergistic anticancer effect of green synthesized nickel. Herbs have been provided therapeutic potential to the health of individual. Holy basil is possibly safe when used by mouth for short periods of time, up to six weeks. International journal of basic and applied research phytochemical screening, antimicrobial, antioxidant and anticancer activity of ocimum sanctum plant extract article aug 2018. It is universally cultivated as herbaceous, perennial plant but originated from asian continent. Compounds 6, 7, 9, 11, 12, and, along with the methanol.
Ocimum sanctum linn tulsi is a wellknown plant used in the indian system of medicine. Ocimum tenuiflorum an overview sciencedirect topics. Antimicrobial activity of tulsi ocimum tenuiflorum. Labiatae, a plant with various medicinal properties, has been investigated against human fibrosarcoma cells hfs cells in culture. Medicinal properties, ocimum sanctum os, tulsi, pharmacological activities. Tulsi the wonder herb pharmacological activities of ocimum sanctum sai krishna. Ocimum sanctum tulsi is an indian medicinal plant known to possess hypoglycemic, hypolipidemic, immunomodulatory, adaptogenic, hepatoprotective, and cardioprotective activities. Because of high death rate associated with cancer and because of serious side effects of chemotherapy and radiation therapy, many cancer patients seek alternative complementary methods of treatment. Antioxidant, anticancer and molecular docking activity of.
Tulsi the wonder herb pharmacological activities of. Ocimum sanctum plant leaves were subject to sequential solvent fractionation with different polarity hexane, chloroform, nbutanol and water. Eugenol 1hydroxy2methoxy4allylbenzene is the active constituents present in ocimum sanctum linn. Ocimum sanctum has excellent antimalarial properties, eugenol the main constituent of this plant is responsible for its repellant property singh et al. Fixed oil and linolenic acid present in tulsi have the ability to.
The present study was designed to investigate the antioxidant and anti neoplastic activities of ocimum sanctum linn. Leaves and flowering tops are used for extracting essential oil. Phytochemical analysis for the important chemical constituents from ethanolic extract was carried out. Ocimum contains fixed oil which is confirmed by chemical tests for glycerine. Review article chemical constituents and pharmacological. Not enough is known about the use of holy basil during pregnancy and breastfeeding. The best known species are the strongly aromatic herb ocimum basilicum thai basil and ocimum gratissimum african basil as well as the medicinal herb ocimum tenuiflorum, also known as ocimum sanctum holy basil or tulsi in hindi.
Medicines free fulltext antiproliferative activity of. It has been found that ethanolic extract of ocimum sanctum mediated a significant reduction in tumor cell size and an increase in lifespan of mice having sarcoma180 solid tumors 10. Cancer is the abnormal growth of cells in our bodies that can lead to death. Evaluation of antidiabetic and antihyperlipidemic effects. Ocimum sanctum contain several bioactive compounds may contribute to the health effects and are easily available for consumption to increase the nutritional status as well as act as safe guarding against possible deficiencies. Scientific studies have shown it to possess antiinflammatory, analgesic, antipyretic, antidiabetic, hepatoprotective, hypolipidemic. In conclusion this article provides the knowledge about anticancer. Its leaves are helpful in sharpening memory and in curing fever and common cold. Evaluation of antidiabetic and antihyperlipidemic effects of hydroalcoholic extract of leaves of ocimum tenuiflorum lamiaceae and prediction of biological activity of its. Study on anticancer effects of ocimum sanctum and withania somnifera on experimentally induced cancer in mice. Phytochemical analysis, antibacterial and antioxidant. Different parts of ocimum sanctum like roots, stem, leaves, flowers and seeds possess medicinal properties and are used for treatment for many pathologic conditions as analgesic, antipyretic, anticancer, expectorant.
Antimicrobial activity of ocimum sanctum extract was carried out using well diffusion method by comparing the clear inhibition zone of standard antibiotic and. Antibacterial, antifungal, antioxidant, anticancer, antiulcer pharmacological properties of ocimum species viz. Pdf the anticancer effect of ocimum tenuiflorum leaves. Antiinflammatory activity of extracted eugenol from. Ocimum sanctums methanolic extract 500mg proved the inflammatory activity in rats. Constituents of the essential oil from the holy basil or tulsi plant, ocimum sanctum. Basil is the main ingredient of pesto sauce but is also used to flavor other sauces and soups.
Biosynthesis of gold nanoparticles using ocimum sanctum. Os, tulsi, a medicinal herb used in the indigenous system of medicine. It is particularly good for reducing depression, stress and anxiety. An investigation was carried out to study the antioxidant, anticancer and docking activities of medicinal plant, tulsi ocimum sanctum. Phytochemical analysis of medicinal herb ocimum sanctum. Promotes healthy heart holy basil contains vitamin c and antioxidants such as eugenol, which protects the heart from the harmful effects of free radicals. These observations conclude ocimum sanctum extracts possess anticancer activity22. Study of invitro antioxidant and antibacterial activity of leaf extract of azadirachta indica and ocimum sanctum in different organic solvents and cow urine.
They observed that, the ocimum sanctum linn has also been suggested to possess, anticancer, antidiabetic, antifertility, antifungal, antimicrobial, cardio protective, analgesic, antispasmodic and adaptogenic actions. The anticancer activity of os has been proved and cited by several investigators8 11. This result has also been demonstrated by anticancer activity of ocimum sanctum in lewis lung carcinoma animal model. Phytochemical screening and antioxidant activity of. Evaluation of some chemical composition, minerals fatty. In vitro and in vivo methods for anticancer activity evaluation and some indian medicinal plants possessing anticancer properties. The antifungal activity of the essential oil of ocimum. Pdf abstract breast cancer is the leading cause of cancer deaths among females in malaysia. Leaf extract of medicinally important plant ocimum sanctum o.
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